姚帆 博士、教授、博士生导师
教育经历：
2006-2012年 中科院上海生命科学研究院 生物化学与分子生物学 博士
2002-2006年 武汉大学 生命科学与技术基地班 学士
工作经历与任职：
2020- 至今 必赢nn699net 必赢nn699net 生命科学技术学院 教授
2019-2020 年 美国得州大学MD安德森癌症中心 讲师
2014-2019 年 美国得州大学MD安德森癌症中心 博士后
2012-2013 年 中科院上海生命科学研究院营养科学研究所 助理研究员
研究方向：
肿瘤发生发展分子机制，肿瘤治疗耐受分子机制：
1. 利用遗传小鼠模型研究肺癌和肝癌发生发展机制；
2. 利用CRISPR-Cas9筛选亚库筛选并鉴定肺癌和肝癌治疗耐受的形成机制，为肿瘤治疗提供新的靶点和手段；
3. 利用小鼠肿瘤模型和人肿瘤组织来源的移植瘤模型（Patient-derived xenograft, PDX）鉴定并评估靶点分子抑制剂的治疗效果。
代表论文(*共同第一作者，#共同通讯作者)：
1. Yao F*#, Deng Y*, Zhao Y, Mei Y, Zhang Y, Liu X, Martinez C, Su X, Rosato R, Teng H, Hang Q, Yap S, Chen D, Wang Y, Chen M, Zhang M, Liang H, Xie D, Chen X, Zhu H, Chang J, You J, Sun Y, Gan B, Ma L#. A targetable LIFR- NF-κB -LCN2 axis controls liver tumorigenesis and vulnerability to ferroptosis. Nature Communications. 2021, 12(1):7333. PMID: 34921145
2. Deng Y, Xia X, Zhao Y, Zhao Z, Martinez C, Yin W, Yao J, Hang Q, Wu W, Zhang J, Yu Y, Xia W, Yao F, Zhao D, Sun Y, Ying H, Hung M, Ma L. Glucocorticoid receptor regulates PD-L1 and MHC-I in pancreatic cancer cells to promote immune evasion and immunotherapy resistance. Nature Communications. 2021, 12(1):7041. PMID: 34873175
3. Hang Q, Zeng L, Wang L, Nie L, Yao F, Teng H, Deng Y, Yap S, Sun Y, Frank SJ, Chen J, Ma L. Non-canonical function of DGCR8 in DNA double-strand break repair signaling and tumor radioresistance. Nature Communications. 2021, 12(1):4033. PMID: 34188037
4. Nie L, Wang C, Li N, Feng X, Lee N, Su D, Tang M, Yao F, Chen J. Proteome-wide Analysis Reveals Substrates of E3 Ligase RNF146 Targeted for Degradation. Molecular and Cellular Proteomics. 2020, 19(12):2015-2030. PMID: 32958691
5. Zhao Y, Teng H, Yao F, Yap S, Sun Y, Ma L. Challenges and Strategies in Ascribing Functions to Long Noncoding RNAs. Cancers (Basel). 2020 Jun 3; 12(6):1458. PMID:32503290
6. Yao F, Ma L. piRNA-unbound PIWIL1 promotes metastasis. Nature Cell Biology. 2020 Apr;22(4):359-360. PMID: 32203422
7. Kim J, Piao HL, Kim BJ, Yao F, Han Z, Wang Y, Xiao Z, Siverly AN, Lawhon SE, Ton BN, Lee H, Zhou Z, Gan B, Nakagawa S, Ellis MJ, Liang H, Hung MC, You MJ, Sun Y, Ma L. Long noncoding RNA MALAT1 suppresses breast cancer metastasis. Nature Genetics. 2018 Dec;50(12):1705-1715. PMID: 30349115
8. Yao F, Xiao Z, Sun Y, Ma L. SKP2 and OTUD1 govern non-proteolytic ubiquitination of YAP that promotes YAP nuclear localization and activity. Cell Stress. 2018 Aug 14;2(9):233-235. PMID: 31225491
9. Yao F, Zhou Z, Kim J, Hang Q, Xiao Z, Ton BN, Chang L, Liu N, Zeng L, Wang W, Wang Y, Zhang P, Hu X, Su X, Liang H, Sun Y, Ma L. SKP2- and OTUD1-regulated non-proteolytic ubiquitination of YAP promotes YAP nuclear localization and activity. Nature Communications. 2018 Jun 11;9(1):2269. PMID: 29891922
10. Zhang P, Xiao Z, Wang S, Zhang M, Wei Y, Hang Q, Kim J, Yao F, Rodriguez-Aguayo C, Ton BN, Lee M, Wang Y, Zhou Z, Zeng L, Hu X, Lawhon SE, Siverly AN, Su X, Li J, Xie X, Cheng X, Liu LC, Chang HW, Chiang SF, Lopez-Berestein G, Sood AK, Chen J, You MJ, Sun SC, Liang H, Huang Y, Yang X, Sun D, Sun Y, Hung MC, Ma L. ZRANB1 Is an EZH2 Deubiquitinase and a Potential Therapeutic Target in Breast Cancer. Cell Reports. 2018 Apr 17;23(3):823-837. PMID: 29669287
11. Ge Z, Leighton JS, Wang Y, Peng X, Chen Z, Chen H, Sun Y, Yao F, Li J, Zhang H, Liu J, Shriver CD, Hu H; Cancer Genome Atlas Research Network, Piwnica-Worms H, Ma L, Liang H. Integrated Genomic Analysis of the Ubiquitin Pathway across Cancer Types. Cell Reports. 2018 Apr 3;23(1):213-226.e3. PMID: 29617661
12. Kim J, Yao F, Xiao Z, Sun Y, Ma L. MicroRNAs and metastasis: small RNAs play big roles. Cancer and Metastasis Reviews. 2018 Mar;37(1):5-15. PMID: 29234933
13. Zhou Z, Zhang P, Hu X, Kim J, Yao F, Xiao Z, Zeng L, Chang L, Sun Y, Ma L. USP51 promotes deubiquitination and stabilization of ZEB1. American Journal of Cancer Research. 2017 Oct 1;7(10):2020-2031. PMID: 29119051
14. Bao WD, Yao F, Deng YZ, Long LY, Wang JJ, Guan DX, Qian ZY, An P, Feng YY, He ZY, Wang XF, Phillip Koeffler H, Hu R, Wang J, Wang X, Wang F, Li JJ, Xie D. Iron overload in hereditary tyrosinemia type 1 induces liver injury through the Sp1/Tfr2/hepcidin axis. Journal of Hepatology. 2016 Jul;65(1):137-145. PMID: 27013087
15. Long L, Deng Y, Yao F, Guan D, Feng Y, Jiang H, Li X, Hu P, Lu X, Wang H, Li J, Gao X, Xie D. Recruitment of the phosphatase PP2A by RACK1 adaptor protein deactivates the transcription factor IRF3 and limits type I interferon signaling. Immunity. 2014 Apr 17;40(4):515-29. PMID: 24726876
16. Yao F, Long LY, Deng YZ, Feng YY, Ying GY, Bao WD, Li G, Guan DX, Zhu YQ, Li JJ and Xie D. RACK1 modulates NF-kappaB activation by interfering with the interaction between TRAF2 and the IKK complex. Cell Research. 2014 Mar;24(3):359-71. PMID: 24323043
17. Deng YZ, Yao F, Li JJ, Mao ZF, Hu PT, Long LY, Li G, Ji XD, Shi S, Guan DX, et al. RACK1 suppresses gastric tumorigenesis by stabilizing the beta-catenin destruction complex. Gastroenterology. 2012 Apr;142(4):812-823.e15. PMID: 22240482
18. Feng YX, Wang T, Deng YZ, Yang P, Li JJ, Guan DX, Yao F, Zhu YQ, Qin Y, Wang H, et al. Sorafenib suppresses postsurgical recurrence and metastasis of hepatocellular carcinoma in an orthotopic mouse model. Hepatology. 2011 Feb;53(2):483-92. PMID: 21274870
研究生招生专业：
肿瘤生物学，生物化学与分子生物学
联系方式：
fyao@mail.hzau.edu.cn
